Evidence appears to be building that direct exposure to natural landscapes characterized by significant green cover, such as forests, can help reduce chronic health conditions such as obesity, stress, hypertension, chronic cardiovascular conditions, depression, anxiety, cancer and diabetes. One way to encourage greater exposure to nature may be through the use of nature prescriptions in which physicians and health care providers recommend that their patients spend time in nature. The presentation will discuss the implementation of a pilot field experiment examining the clinical use of nature-based versus conventional exercise recommendations in the US State of Oregon. We discuss preliminary empirical results related to whether nature prescriptions, offered as one part of a patient’s overall treatment plan, can improve health-related behaviors and self-reported outcomes in clinical settings.  We also identify challenges with such field experiments and offer recommendations for practitioners and researchers interested in implementing and evaluating nature-based exercise programs to improve public health.